iTunes 4.8 is out. It's an update with a fascinating new feature: you can add QuickTime videos to your library, and iTunes knows how to play them. Some music in the iTunes Music Store now comes with videos.
Another big part of iTunes 4.8 is the ability to sync your contacts and calendar with your iPod -- no iSync needed.
For more on iTunes 4.8, check out Chris Breen's article.